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Technology entrepreneur and investor with over 15 years experience at the intersection of…
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Yoni Shtein shared thisMost people assume adding AI to #healthcare care management means less human connection. We're seeing the opposite. AI checks in between calls so every human conversation starts deeper, and handles the admin so clinicians can focus on what matters: care, impact, and empathy.Yoni Shtein shared thisHere's the counterintuitive truth about AI in care management: Adding an AI agent doesn't reduce the human relationship. It deepens it. Every check-in generates context. Every handoff is warm. And instead of starting each call with "how have you been since last time?" — the care manager can start with what they already know. That's the shift from episodic to always-connected care. We unpacked it in our latest post 👇 🔗 https://lnkd.in/ebWG2yXV
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Yoni Shtein shared thisYoni Shtein shared thisOn International Women’s Day, Israel Hayom ישראל היום highlighted women helping lead Israel’s AI revolution, including our Yael Peled Adam, co-founder and CPO of one of Laguna Health, a portfolio company. Yael shared a view we increasingly hear across the ecosystem: 2026 will be the year AI stops being a pilot and becomes real infrastructure inside organizations. In healthcare especially, the real value won’t come from the smartest model, but from companies that know how to integrate AI deeply into existing systems, support decision-making, and deliver measurable impact. Proud to support founders like Yael building the next generation of AI-powered healthcare companies. 👉 Read the full article: https://lnkd.in/dhdqwagN
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Yoni Shtein shared thisQuality and compliance are too important to be sampled, tracked, or reviewed after the fact. Done right, quality means every call, every standard, every workflow is scored, learned, and operationalized. Instead of describing what happened, quality management should shape what happens next! Laguna Insight moves from visibility to Actionable Intelligence! Read more below.Yoni Shtein shared thisIntroducing the new Laguna Insight: Actionable Intelligence Last year, TIME named Laguna Insight one of 2024's Best Inventions. Today, we're taking that foundation and evolving it to transform quality management operations. Laguna Insight now takes YOUR quality forms, YOUR metrics, YOUR workflows — and operationalizes them at scale. → Your evaluation forms: We score every call against it. → Department-specific criteria: Handled. → Human review and nuance: It learns YOUR standards. This isn't just visibility. This is Actionable Intelligence — insights that can drive coaching and automated workflows. Learn more: https://lnkd.in/eUzG5bCb #HealthcareAI #QualityAssurance #TIMEBestInventions #LagunaInsight
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Yoni Shtein shared thisWe’re honored to be recognized by #DHNY this year and for the opportunity to discuss what we look for in an investor partnership. This recognition is a testament to the incredible support we receive from our investors, who champion our vision and share our conviction in every season of business. We're grateful to be on this journey with partners who are truly in it to win it with us! THANK YOU Ittai Harel and Pitango, Richard Lungen and HC9 Ventures, Robby Peters and SemperVirens VC, Nadav Shimoni, M.D. and A-Squared Ventures, and Jonathan Friedman and LionBirdYoni Shtein shared thisHow do founders meet the right funders? And how do funders decide who to back? It’s clear that capital alone is not the only differentiator. Today’s most effective partnerships are defined by shared conviction, operator empathy, and a willingness to stay engaged through the inevitable volatility of building in healthcare. Hear from these founders & funders on what makes a successful partnership. Featuring: Yoni Shtein of Laguna Health | Sam Toole of Primary Venture Partners | Randall Klein of Intention Healthcare | Lindsay Jurist-Rosner of Wellthy | David Whelan of Town Hall Ventures
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Yoni Shtein shared thisSuch a privilege to participate in HC9 Ventures LP Conference panel on #AI in Healthcare with Richard Lungen, Eric Larsen, Mike Vennera, Puneet Maheshwari and Andy Fanning!
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Yoni Shtein shared thisThere’s a growing paradox in AI - less admin burden in exchange for more productivity/intensity. As HBR recently pointed out, AI often doesn’t reduce work but rather intensifies it. https://lnkd.in/eqC-NcTN In healthcare, that makes burnout risk even more acute. When emotional labor meets faster pace and expanded scope, the cost is human. That’s why monitoring, understanding, and actively controlling for burnout has never been more important. Our recent blog post below lays out how we think about doing that the right way. https://lnkd.in/ebGh3Hr3Yoni Shtein shared thisAfter a difficult call delivering a cancer diagnosis, a care manager sits alone with the emotional weight—then has 20 minutes to document everything and prepare for the next member who needs her full attention. This moment, caught between human connection and administrative demands, is where burnout takes root. But what if technology could actually help? Not add more clicks, but give time back. Not create isolation, but break through it. Learn how AI can support the humans of healthcare: https://lnkd.in/eJU65n6M #HealthcareAI #Burnout #CareManagement #HealthTech #CompassionateCare
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Yoni Shtein shared thisHonored to share that Laguna has been named to the Digital Health New York 100 list for the third year in a row. This year we’re especially excited to be recognized in the #Analytics category, reflecting our focus on delivering Actionable Intelligence across administrative efficiency and member engagement. Deep gratitude to the one and only Bunny Ellerin whose energy and vision continue to propel the digital health community forward.Yoni Shtein shared thisThrilled to share that Laguna has been named to the 2026 DH100, published by Digital Health New York and celebrating the most innovative and high-impact digital health startups in NY! It’s our third year in a row, and this year, we're honored to be recognized in the Analytics category. This recognition is a testament to our integrated approach, combining administrative efficiency, member engagement, and powerful analytics to provide ✨Actionable Intelligence✨. As our CEO, Yoni Shtein, said, "Being recognized in Analytics alongside our previous recognition in Administrative Efficiency shows how our integrated approach delivers value across the care continuum." Thank you to the DHNY team for this honor and to our partners and team for their continued support. We're excited to be among the innovative companies shaping the future of healthcare. Read the full announcement here: https://lnkd.in/etqqz4wB #DHNY #DH100 #DigitalHealth #HealthcareAnalytics #ActionableIntelligence
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Yoni Shtein shared thisHear it from the best Yael Peled Adam!Yoni Shtein shared thisHeaded to the Tel Aviv Sparks Innovation Festival? Our Co-founder and CPO, Yael Peled Adam, will be joining an expert panel to discuss "AI in Healthcare: The New Frontier of Diagnostics and Personalized Medicine." Want to join the session? We have a few complimentary passes to share. Register here: https://lnkd.in/dFcjTtcx Use Code: PaSPK26LinkD See you there! #TelAvivSparks #LagunaHealth #HealthTech
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Yoni Shtein reacted on thisYoni Shtein reacted on thisAre AI agents creating very bad unit economics for many healthcare companies? In the 2021 bubble, headcount and hiring were considered proxies for success. But when the dust settled, it became apparent that many businesses suffered from negative unit economics due to the surplus of labor that was embedded in their margins. Today we hear so much about the new type of companies that rely on very small teams to deliver more. Lower headcount. Faster workflows. Better margins. Or is it not? Truth is, most of them have negative (!) unit economics that are getting worse as they scale. 2021 all over. These companies have less human employees but are relying on different labor (agents) which is not necessarily less expensive than human labor and is just a different 'compensation' structure, i.e. Tokens. And like in 2021, when some companies will start facing reality and reach a fundraising celling, things won’t be pretty. I’ll try to break it down. In 2021, We saw a wave of tech-enabled services dressed up as software. But underneath these had: • High human labor dependency • Low real automation • Fragile contribution margins Growth masked it. Zero rate capital subsidized it. Today, replace “humans” with tokens, and you get a similar picture. Maybe even more problematic. It is very easy to forget that even a simple task can mean a lot of tokens. And like cloud consumption, these are mouse traps that start as something relatively cheap but if not planned very wisely, token consumption skyrockets. In other words, the fact that a company is small (number of human employees) doesn’t mean it is efficient. We are just shifting cost from payroll to computing. Every workflow = tokens consumed Every automation = inference cost Every “AI employee” = variable expense This situation is compounded in healthcare. Workflows are messy, regulated, and exception-heavy. So what actually happens in practice: You run multiple models per task (clinical, QA, compliance) You keep humans in the loop (risk, liability, regulation) You build layers of orchestration (more tokens) Therefore in my opinion, metrics like revenue per employee or gross margin are irrelevant. (like in 2021!), and again we need to look at bottom lines. Contribution margins Cost per completed workflow Cost per claim / visit / patient Net revenue retention And most importantly, how those evolve as usage scales AI will absolutely reshape healthcare. Agents will be part of every workflow. But the companies that win won’t be the ones that use AI the most, but use it efficiently. And I’m betting we will find a correlation between companies that raise too much, too soon to inefficient, rapid consumption of AI. We’ve seen this movie before, just with a different type of employee.
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Yoni Shtein liked thisYoni Shtein liked thisPREDICTION: Anthropic will surpass Alphabet in revenue by mid-2028. This is not a bull case or an acceleration scenario — it is a continuation of the curve already in evidence. Anthropic’s ARR went from $1B (Jan 2025) to $9B (Dec 2025) to $30B (Apr 2026) — a 3.3x step in a single four-month window, and the curve has been steepening, not flattening. My projection actually assumes deceleration from here: $100B by end of 2026, $340B in 2027, $850B in 2028, $1.4T in 2029, $2T by 2030. Crossover with Alphabet happens at ~$575B in mid-2028, not because Anthropic accelerates beyond today’s pace, but because Alphabet — locked at ~15% YoY in a mature ads-and-cloud business — cannot match enterprise AI’s adoption physics. As Rory O'Driscoll intelligently observed recently, Gemini tokens served grew by only 60% in the last quarter … while Anthropic grew by 10X. Three drivers make the continuation structural, not speculative: customers spending >$1M/year with Anthropic doubled from 500 to 1,000 in under two months post-Series G (these are multi-year expanding contracts with near-zero churn — switching a deployed agent stack mid-flight is operationally untenable); Claude Code is the wedge, not the product, dragging the rest of the platform — agents, MCP, healthcare, biotech — into every Fortune 2000 deployment as an attach point; and compute supply is finally non-binding with the 3.5GW Google + Broadcom deal (2027+), this weeks SpaceX partnership, and 1GW of standing Google capacity for 2026. For most of 2024–2025 the bottleneck was supply, not demand. That constraint is releasing exactly when the demand curve is steepest. The standard objection — “no company has ever sustained this at scale” — applies a software-era frame to a labor-era business. AWS, Azure, and Meta decelerated at $50–100B because they sold tools to the economy. Anthropic is selling cognitive capacity into the economy. The TAM isn’t enterprise software ($800B). It’s labor ($50T+). When the denominator is two orders of magnitude larger, “deceleration at $100B ARR” stops being a law and starts being an assumption. The crossover isn’t a maybe. It’s a function of timing. Mid-2028 is when I think Anthropic surpasses Google.
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Yoni Shtein reacted on thisYoni Shtein reacted on thisToday ZyG announced our A Round, led by Accel. I couldn’t be prouder of all that the ZyG team has achieved in just over a year, the incredible traction to date, and the very clear vision ahead. ZyG OS is positioned to become THE scale platform for eCom, and with partners like Accel and Sonali De Rycker, we have everything we need to make this happen.
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Yoni Shtein reacted on thisYoni Shtein reacted on thisWe are excited to welcome Heather Cianfrocco as our new chief operating officer. A Pittsburgh native, Heather brings both deep community roots and health care industry leadership with her to the organization. Reporting to Highmark Health President Karen Hanlon, Heather will play a key role in driving the innovation and change essential to execute the next phases of our #LivingHealth strategy. Welcome, Heather! Learn more: https://lnkd.in/eXRHy6Cm
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Yoni Shtein reacted on thisYoni Shtein reacted on thisBefore AI agents. Before NHI was a category. Alon Jackson and Idan Gour were already building the answer. When they pitched Adam Fisher and me about the company they were launching, Bessemer Venture Partners immediately decided to invest in their seed round. The thesis was clear to us already then — non-human identity security was one of the most underinvested problems in enterprise security. But what sealed it was Alon and Idan. The spark in Alon's eyes when he talked about this problem was unmistakable. So is what he and Idan had together - a founding chemistry so tight you could almost swap their roles seamlessly. Alon's relentless energy. Idan's ability to win the trust of any CISO in the room. Formidable from day one. The rise of AI agents turned their early conviction into one of the hottest categories in cyber. It is not surprising that Cisco saw it too. Congratulations to Alon Jackson, Idan Gour, and the whole Astrix Security team. And thank you to F2 Venture Capital, CRV, and Menlo Ventures for building this alongside us. In the pictures: with my colleague Yael Schiff after signing the TS, and with Ofer Smadari and Yoav Regev at Blackhat. https://lnkd.in/djGw-TWd
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Yoni Shtein reacted on thisYoni Shtein reacted on this🚨 NEVER waste time on busy work again. These 18 plug-and-play Claude Skills do 80% of your daily work for you. Most people use Claude like a chatbot. Type a prompt. Get a response. Start over. That's fine. But it's not a workflow. Real workflows look like this: → Your meeting notes are already summarized with action items → You type one prompt and get a full competitive analysis from 20+ sources → You paste a doc and get a client-ready proposal back in 90 seconds → Your weekly report writes itself from your actual work Most business owners still do all of this manually. I packaged 18 ready-to-use Claude Skills and workflows into one free guide: → Auto meeting debrief with action items and owners → One-prompt competitive analysis from 20+ sources → Client proposal builder from raw conversation notes → Weekly status report that writes itself from real work → Morning briefing with your top priorities for the day → Follow-up tracker that catches forgotten commitments → Email drafter that uses context from actual conversations Each one includes the exact prompt, the setup steps, and example output. No coding. No setup. Copy, paste, run. Want the full 18-skill workflow guide? 1. Connect with me 2. Comment "SKILLS" I'll send it over.
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Yoni Shtein reacted on thisYoni Shtein reacted on thisKintsugi spent seven years and $30 million building a clinically validated, FDA-cleared AI diagnostic. They still dissolved voluntarily. For context: Kintsugi built a vocal biomarker platform that could detect depression and anxiety. They didn't analyze what you said. Just how you said it. Pitch, speech rate, pauses. Twenty seconds of audio was enough to flag signals of depression and anxiety that standard screening completely missed. Giovanni Colella, MD, MBA wrote a great piece on what happened and I'd recommend reading it. The short version: they did everything right. FDA De Novo clearance pathway, peer-reviewed research, prospective double-blind pivotal study. Four years of regulatory navigation. But the capital clock ran out before the regulatory clock finished. The article puts it well: the responsible choice is also the suicidal one. Go full FDA pathway for clinical AI and you're on a timeline structurally incompatible with how venture capital works. Which is a shame. Because going through regulatory clearance and building as a certified medical device is the only real guarantee that clinical AI is safe, validated, and actually does what it claims. But right now in the US, skipping that is becoming almost fashionable. Deregulation tailwinds, clinical AI built without a physician in the room, two-person GLP-1 startups chasing hypergrowth. Not following regulatory and compliance pathways is quietly becoming the smart commercial move. Kintsugi is not the first casualty of this dynamic and won't be the last. Sword is one of the very few examples I know of that has managed both — real hypergrowth and doubling down on clinical rigor / medical device certification. It's rare and I don't think people appreciate how rare. Tldr; The market is not rewarding the people trying to build responsible clinical AI. That should worry all of us. PS: Credit to Grace Chang and the Kintsugi team for how they handled the shut down situation. Rather than letting the work disappear, they open-sourced the models, the methodologies, the research. Classy! Source --> giovannicolella336816(dot)substack(dot)com/p/the-most-responsible-path-in-healthcare
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Yoni Shtein reacted on thisToday, I'm so excited to share that we have successfully closed our transaction to become a part of Spring Health! I started Alma from a belief that the single biggest challenge facing healthcare, and our society more broadly, was a lack of access to quality mental health. I’m so grateful to the providers, clients, payers, and Alma team members who have brought us to this point. And I know how much there is left to do. April Koh and Adam Chekroud have inspired me with their vision for the future - building a platform that can hold a member in continuous, high quality care throughout the phases of their life. I am grateful for their leadership and excited to be part of the team!Yoni Shtein reacted on thisToday, we’re excited to share that we have successfully closed our transaction to become a part of the Spring Health family. 🌱 We’re stepping into this next chapter energized by the opportunities in front of us to better serve patients, providers, and our payer partners. Together, we’re better positioned to achieve our mission and deliver mental health care people can rely on, even as their needs and coverage change. Read the full announcement here: https://lnkd.in/ewv28k5VSpring Health and Alma Complete Combination, Creating the First Lifelong Mental Health Platform | Spring HealthSpring Health and Alma Complete Combination, Creating the First Lifelong Mental Health Platform | Spring Health
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Education
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Harvard Business School
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Activities and Societies: Co-President of the Jewish Student Association. Member of High Tech & New Media, Entrepreneurship, Venture Capital & Private Equity clubs.
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Eze Vidra
Tips for Israeli founders looking to raise a pre-seed in 2026 🇮🇱🚀 1. Speed and execution matters more than polish Show early signals of customer "obsession," not just "interest." Traction and data are now weighted more heavily than market size. 2. Narrative > numbers (at pre-seed) Show a sharp wedge, clear why-now, and why-you. Early traction helps, but clarity wins. 3. AI is everywhere but differentiation isn’t “AI-powered” is table stakes. Your edge should be data, distribution, workflow, or cost curve. 4. Sell the insight, not the market size Huge markets are easy to claim. A non-obvious insight is harder to copy. What did you figure out early that most have overlooked? 5. Bridge the Tel Aviv-to-US Gap Early US funds are moving upstream into the Israeli pre-seed stage. The "entry fee" is a clear North American Go-To-Market strategy baked. If you aren't thinking global on Day 1, you're invisible. The capital is there… but the "flight to quality" is at an all-time high. The bar for Pre-Seed today looks a lot like the bar for Seed three years ago. Israeli founders in stealth thinking about raising pre-seed in 2026? happy to give you a quick answer and provide you with friendly VC feedback on the pitch. We did 9 deals at Remagine Ventures in 2025 and excited to make our first investment in 2026! Pictured: catching up with a friend in NYC this week, cartoonified. Guess the place and person?
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Ish Dugal
Replit just raised $400M at a $9B valuation — and IronArc Ventures doubled down with a sizable investment. We first backed Replit because we believed software creation should be accessible to everyone, not just engineers. That thesis is playing out faster than anyone expected. 50M+ users. 85% of the Fortune 500. On track for $1B in run-rate revenue by year-end. And today they launched Agent 4 — 10x faster than its predecessor. But the numbers aren't what excite me most. It's watching a CMO prototype partnership ideas on game day. My kids building their own video games. Employees spinning up internal tools in hours instead of weeks. Thanks to Amjad Masad Alexander Bibic Robert Kohse and the Replit team for pursuing the mission to bring a billion creators online. Every quarter, that vision looks less ambitious and more inevitable. Congrats to the entire Replit team. We're proud to be part of this journey. CC: IronArc Ventures #Replit #AI #VibeCoding #Venture
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Jonathan 'Yoni' Frenkel
$3B valuation and $760M raised. Here’s how Yotam Segev and Tamar Bar-Ilan achieved this just 3 years in. They didn’t build a startup. They built a defense system for the digital age. Before Cyera became a $3B company, before raising $760M from the best in the game and before defining the entire DSPM category, Yotam Segev and Tamar Bar-Ilan were deep inside Unit 8200 - Israel’s elite cyber-intelligence unit. They were: → Protecting data at a national scale. → They weren’t spitballing startup ideas. → They were running real ops and solving real threats. Years before the rest of us saw them coming. So when they launched Cyera in 2021, it wasn’t a guess. It was a mission - a platform that understands data, not just protects it. 1. Total mapping 2. Real-time visibility 3. Cloud-native security Today? Cyera is trusted by Fortune 100s, is backed by Accel, Sequoia, Redpoint, and is growing at hyperspeed. This isn’t the usual founder story. It’s what happens when military-grade precision meets category-defining execution. And they’re not building noise. They’re building the new normal. - - - - - Who else is building with this kind of depth and clarity? (Image by Ohad Kab - DADA STUDIO x YKC Media )
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Kasey Z.
With RL techniques like GRPO, it’s become easy to fine-tune small models to outperform foundation models on vertical tasks. We’re open sourcing Osmosis-Apply-1.7B: a small model that merges code (similar to Cursor’s instant apply) better than foundation models. Links in comments! Using foundation models for high specificity, low complexity tasks like code merging can be overkill - instead, it’s better to use a specialized model instead for higher performance and latency. We fine-tuned the model on 100K real-world code commits where the model needs to merge a code edit snippet into an original code snippet. On the test dataset (subset of CommitPackFT), foundation model performance ranged between 0.77-0.93 reward score. In comparison, Osmosis-Apply-1.7B achieved a 0.98 reward score - while also being 3X-5X more affordable than the next cheaper model AND ~10X faster! Why this matters: the best AI agents use multiple models to ensure task specialization and reliability at scale - on top of cost and latency benefits as well. Links to the model and full write-up (with reward function, hyperparameters, etc.) are in the comments - reach out if you’re interested in using reinforcement learning!
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Shachi Shah
𝗪𝗵𝘆 𝘄𝗲 𝗯𝗮𝗰𝗸𝗲𝗱 𝘁𝗵𝗲 "𝗢𝗽𝗲𝗿𝗮𝘁𝗶𝗻𝗴 𝗦𝘆𝘀𝘁𝗲𝗺" 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗜 𝗖𝗹𝗼𝘂𝗱. When we first met the team at hosted·ai, one stat blew us away: AI workloads often consume only 40% of the GPU capacity they are paying for. In the Gold Rush of 2026, everyone is selling shovels. But hosted.ai is building the automated machinery that makes those shovels work 24/7. They announced their Series A to scale their mission of making GPU infrastructure simple, affordable, and—most importantly—profitable for providers outside the "Big Three" hyperscalers. It’s rare to find a team with this much "scar tissue" in infrastructure (25+ years of experience) tackling the most pressing bottleneck in tech today. Onward and upward! 📈 #Startups #Founders #AI #GPUaaS #InvestmentNews z21 Ventures Raj Shekhar Singh Jyotika Gupta Sudarshan Ravi Udit Batish Carl Fritjofsson
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PropTech Connect
Visitt announced that it has raised $22 million in Series B funding from Susquehanna Growth Equity (SGE), with participation from existing investors Vertex Ventures Israel, Anfield Ltd, and Sarona Ventures. Itay Oren, CEO and Co-founder of Visitt, said: “Operators need speed, clarity, and real outcomes through a single interface with AI built into the operational core.” He added, “This investment allows us to accelerate innovation while staying true to how we operate: as true partners with our customers, building in their buildings and supporting their success. SGE shares our commitment to supporting property teams, bringing valuable experience from its real estate technology investments.” “We are thrilled to partner with Itay and his talented team, who have built a best-in-class platform through relentless commitment to solving common issues in the commercial real estate industry,” said Josh Elser, Managing Director, Susquehanna Growth Equity. “Visitt is well-positioned to capture a massive whitespace opportunity, and we are eager to support the entire team as they continue to scale the platform.” Tobias Lange, Investor, Susquehanna Growth Equity, added, “We’ve been tremendously impressed with Visitt’s user-friendly AI workflows, which enhance commercial real estate building operations and tenant experience, driving higher satisfaction and measurable ROI for owners and operators.” 💡 200,000+ construction and proptech leaders stay ahead with weekly insights on AI, investment, and innovation. 👉 Sign up via the form at the bottom of the page linked above
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Yoav Leitersdorf
YL Ventures is thrilled to share that Hush Security has launched from stealth with an $11M #seed round from YL Ventures and Battery Ventures! Congratulations to cofounders Micha Rave, Shmulik Ladkani, Alon Horowitz and Chen Nisnkorn - a seasoned team whose track record includes building Meta Networks (acquired by Proofpoint). Machine identities have quietly become the backbone of modern infrastructure, yet remain one of the least governed, least secured parts of the #enterprise. Hush Security is changing that, not by incrementally improving the old vault model, but by introducing an entirely new paradigm: #secretless, policy-based access that scales at the speed of today’s environments. With #Fortune500 enterprises already adopting the platform, Hush Security is positioned to define the future of machine identity #security. This is just the beginning, and we look forward to seeing the impact they will make across the industry! Read more here: https://lnkd.in/g97JvQqZ
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